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  <front>
    <journal-meta>
      <journal-id journal-id-type="eissn">2713-2900</journal-id>
      <journal-title-group>
        <journal-title xml:lang="ru">Вестник УГМУ</journal-title>
        <journal-title xml:lang="en">USMU Medical Bulletin</journal-title>
      </journal-title-group>
      <publisher>
        <publisher-name>Уральский государственный медицинский университет</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.52420/usmumb.10.3.e00172</article-id>
      <article-id pub-id-type="edn">https://elibrary.ru/DNQGQC</article-id>
      <article-id pub-id-type="uri">https://vestnikusmu.ru/index.php/vestnik/article/view/172</article-id>
      <title-group>
        <article-title xml:lang="ru">Задержка в диагностике ишемического инсульта у детей раннего возраста: результаты пилотной оценки клинических и нейровизуализационных данных</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>Delay in the Diagnosis of Ischemic Stroke in Early Childhood: Results of a Pilot Assessment of Clinical and Neuroimaging Data</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name name-style="eastern">
            <surname>Мешков</surname>
            <given-names>Алексей Владимирович</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Мешков</surname>
              <given-names>Алексей Владимирович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Meshkov</surname>
              <given-names>Alexey V.</given-names>
            </name>
          </name-alternatives>
          <email>almeshkov@ya.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Жуков</surname>
            <given-names>Вадим Анатольевич</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Жуков</surname>
              <given-names>Вадим Анатольевич</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Zhukov</surname>
              <given-names>Vadim A.</given-names>
            </name>
          </name-alternatives>
          <email>dmb9@mail.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Шовкопляс</surname>
            <given-names>Светлана Викторовна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Шовкопляс</surname>
              <given-names>Светлана Викторовна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Shovkoplyas</surname>
              <given-names>Svetlana V.</given-names>
            </name>
          </name-alternatives>
          <email>shovkoplaysik@mail.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Муллаяров</surname>
            <given-names>Роберт Фанусович</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Муллаяров</surname>
              <given-names>Роберт Фанусович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Mullayarov</surname>
              <given-names>Robert F.</given-names>
            </name>
          </name-alternatives>
          <email>r-mullayarov@yandex.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Львова</surname>
            <given-names>Ольга Александровна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Львова</surname>
              <given-names>Ольга Александровна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Lvova</surname>
              <given-names>Olga A.</given-names>
            </name>
          </name-alternatives>
          <email>olvova74@gmail.com</email>
          <contrib-id contrib-id-type="orcid">0000-0002-2280-3096</contrib-id>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Орлова</surname>
            <given-names>Елена Александровна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Орлова</surname>
              <given-names>Елена Александровна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Orlova</surname>
              <given-names>Elena A.</given-names>
            </name>
          </name-alternatives>
          <email>leshka-aleshka78@yandex.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Сулимов</surname>
            <given-names>Алексей Валентинович</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Сулимов</surname>
              <given-names>Алексей Валентинович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Sulimov</surname>
              <given-names>Alexey V.</given-names>
            </name>
          </name-alternatives>
          <email>sulimovekb@yandex.ru</email>
          <contrib-id contrib-id-type="orcid">0009-0007-6459-4978</contrib-id>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Межирицкая</surname>
            <given-names>Мария Семёновна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Межирицкая</surname>
              <given-names>Мария Семёновна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Mezhiritskaya</surname>
              <given-names>Maria S.</given-names>
            </name>
          </name-alternatives>
          <email>masha18a@mail.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Коваленко</surname>
            <given-names>Светлана Дмитриевна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Коваленко</surname>
              <given-names>Светлана Дмитриевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Kovalenko</surname>
              <given-names>Svetlana D.</given-names>
            </name>
          </name-alternatives>
          <email>kovalenko.s.d@mail.ru</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Бердюгин</surname>
            <given-names>Игорь Николаевич</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Бердюгин</surname>
              <given-names>Игорь Николаевич</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Berdyugin</surname>
              <given-names>Igor N.</given-names>
            </name>
          </name-alternatives>
          <email>3230634@gmail.com</email>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Короткова</surname>
            <given-names>Екатерина Владимировна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Короткова</surname>
              <given-names>Екатерина Владимировна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Korotkova</surname>
              <given-names>Ekaterina V.</given-names>
            </name>
          </name-alternatives>
          <email>evkmob@gmail.com</email>
          <contrib-id contrib-id-type="orcid">0000-0001-8601-3192</contrib-id>
          <xref ref-type="aff" rid="aff4"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Тарасов</surname>
            <given-names>Дмитрий Александрович</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Тарасов</surname>
              <given-names>Дмитрий Александрович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Tarasov</surname>
              <given-names>Dmitrii A.</given-names>
            </name>
          </name-alternatives>
          <email>dmitry.tarasov@urfu.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0001-7490-7439</contrib-id>
          <xref ref-type="aff" rid="aff4"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Шалагина</surname>
            <given-names>Ирина Андреевна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Шалагина</surname>
              <given-names>Ирина Андреевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Shalagina</surname>
              <given-names>Irina A.</given-names>
            </name>
          </name-alternatives>
          <email>trotskaya-03@mail.ru</email>
          <xref ref-type="aff" rid="aff5"/>
        </contrib>
        <aff-alternatives id="aff1">
          <aff>
            <institution xml:lang="ru">Детская городская клиническая больница № 9 (Екатеринбург, Россия)</institution>
          </aff>
          <aff>
            <institution xml:lang="en">Children’s City Clinical Hospital No. 9 (Ekaterinburg, Russia)</institution>
          </aff>
        </aff-alternatives>
        <aff-alternatives id="aff2">
          <aff>
            <institution xml:lang="ru">Детская городская клиническая больница № 9; Уральский государственный медицинский университет; Уральский федеральный университет имени первого Президента России Б. Н. Ельцина (Екатеринбург, Россия)</institution>
          </aff>
          <aff>
            <institution xml:lang="en">Ural State Medical University; Ural State Medical University; Ural Federal University named after the first President of Russia B. N. Yeltsin (Ekaterinburg, Russia)</institution>
          </aff>
        </aff-alternatives>
        <aff-alternatives id="aff3">
          <aff>
            <institution xml:lang="ru">Детская городская клиническая больница № 9; Министерство здравоохранения Свердловской области (Екатеринбург, Россия)</institution>
          </aff>
          <aff>
            <institution xml:lang="en">Children’s City Clinical Hospital No. 9; Ministry of Health of the Sverdlovsk Region (Ekaterinburg, Russia)</institution>
          </aff>
        </aff-alternatives>
        <aff-alternatives id="aff4">
          <aff>
            <institution xml:lang="ru">Уральский федеральный университет имени первого Президента России Б. Н. Ельцина (Екатеринбург, Россия)</institution>
          </aff>
          <aff>
            <institution xml:lang="en">Ural Federal University named after the first President of Russia B. N. Yeltsin (Ekaterinburg, Russia)</institution>
          </aff>
        </aff-alternatives>
        <aff-alternatives id="aff5">
          <aff>
            <institution xml:lang="ru">Уральский государственный медицинский университет (Екатеринбург, Россия)</institution>
          </aff>
          <aff>
            <institution xml:lang="en">Ural State Medical University (Ekaterinburg, Russia)</institution>
          </aff>
        </aff-alternatives>
      </contrib-group>
      <pub-date pub-type="epub" iso-8601-date="2025-09-30">
        <day>30</day>
        <month>09</month>
        <year>2025</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2025</year>
      </pub-date>
      <volume>10</volume>
      <issue>3</issue>
      <elocation-id>e00172</elocation-id>
      <permissions>
        <copyright-statement>© Мешков А.В., Жуков В.А., Шовкопляс С.В., Муллаяров Р.Ф., Львова О.А., Орлова Е.А., Сулимов А.В., Межирицкая М.С., Коваленко С.Д., Бердюгин И.Н., Короткова Е.В., Тарасов Д.А., Шалагина И.А., 2025. Материал доступен по условиям лицензии CC BY-NC-SA 4.0 Int.</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder xml:lang="ru">Мешков А.В., Жуков В.А., Шовкопляс С.В., Муллаяров Р.Ф., Львова О.А., Орлова Е.А., Сулимов А.В., Межирицкая М.С., Коваленко С.Д., Бердюгин И.Н., Короткова Е.В., Тарасов Д.А., Шалагина И.А.</copyright-holder>
        <copyright-holder xml:lang="en">Meshkov A.V., Zhukov V.A., Shovkoplyas S.V., Mullayarov R.F., Lvova O.A., Orlova E.A., Sulimov A.V., Mezhiritskaya M.S., Kovalenko S.D., Berdyugin I.N., Korotkova E.V., Tarasov D.A., Shalagina I.A.</copyright-holder>
        <license xlink:href="https://creativecommons.org/licenses/by-nc-sa/4.0/">
          <license-p>CC BY-NC-SA 4.0</license-p>
        </license>
      </permissions>
      <self-uri xlink:type="simple" xlink:href="https://vestnikusmu.ru/index.php/vestnik/article/view/172">https://vestnikusmu.ru/index.php/vestnik/article/view/172</self-uri>
      <abstract xml:lang="ru">
        <p>Данные о задержках в диагностике ишемического инсульта (ИИ) у детей практически отсутствуют на российских выборках.&#13;
Цель исследования — оценка времени при постановке диагноза ИИ у детей раннего возраста в детской больнице (Екатеринбург).&#13;
Материалы и методы. 24 ребенка в возрасте 0–36 мес. с подтвержденным ИИ оценены ретроспективно по данным медицинской документации с оценкой времени: «дебют болезни — госпитализация», «дебют болезни — первая нейровизуализация», «госпитализация — первая нейровизуализация», «дебют болезни — постановка диагноза». Также учитывались первый симптом инсульта и факт наличия инфаркта при проведении нейровизуализации.&#13;
Результаты. Первым симптомом инсульта у детей в 58% случаев был парез конечностей. Верный направительный диагноз при поступлении в стационар был в 63% случаев. У 7 детей (29%) нейросонография предшествовала компьютерной или магнитно-резонансной томографии. По данным КТ очаг поражения был виден у 75% пациентов. Среднее время «дебют болезни — госпитализация» — (25,5±40,7) ч.; «дебют болезни — первая нейровизуализация» — (38,7±50,5) ч.; «госпитализация — первая нейровизуализация» — (13,2±33,6) ч.; «дебют болезни — постановка диагноза» — (58,3±82,9) ч.&#13;
Заключение. Ранний детский возраст остается сложным периодом для верного распознавания ИИ, что обусловлено низкой настороженностью врачей неотложного звена, неверным выбором методик нейровизуализации, частым дебютом с общемозговой симптоматикой, а также невозможностью полноценной коммуникации с детьми в силу возраста.</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>Data on delays in the diagnosis of ischemic stroke (IS) in children are practically absent in Russian cohorts.&#13;
The aim of this study was to assess the time to diagnosis of IS in early childhood patients at the children’s hospital (Ekaterinburg).&#13;
Materials and methods. Twenty-four children aged 0–36 months with a confirmed diagnosis of ischemic stroke were retrospectively evaluated based on medical records, assessing the following time intervals: “disease onset to hospitalization”, “disease onset to first neuroimaging”, “hospitalization to first neuroimaging” and “disease onset to diagnosis”. The first symptom of stroke and the presence of infarction on neuroimaging were also recorded.&#13;
Results. The first symptom of stroke in children was limb paresis in 58 % of cases. A correct referral diagnosis at hospital admission was made in 63 % of cases. In 7 children (29 %), cranial ultrasound preceded computed tomography or magnetic resonance imaging. According to CT data, the lesion was visible in 75 % of patients. The mean times were: “disease onset to hospitalization” — (25.5±40.7) hours; “disease onset to first neuroimaging” — (38.7±50.5) hours; “hospitalization to first neuroimaging” — (13.2±33.6) hours; “disease onset to diagnosis” — (58.3±82.9) hours.&#13;
Conclusion. Early childhood remains a challenging period for the accurate recognition of ischemic stroke, due to low clinical suspicion among emergency physicians, inappropriate choice of neuroimaging methods, frequent presentation with nonspecific cerebral symptoms, and the inability to fully communicate with children because of their age.</p>
      </trans-abstract>
      <kwd-group xml:lang="ru">
        <title>Ключевые слова</title>
        <kwd>ишемический инсульт</kwd>
        <kwd>дебют болезни</kwd>
        <kwd>клиника</kwd>
        <kwd>детский возраст</kwd>
        <kwd>нейровизуализация</kwd>
        <kwd>задержка диагностики</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>ischemic stroke</kwd>
        <kwd>debut</kwd>
        <kwd>clinic</kwd>
        <kwd>childhood age</kwd>
        <kwd>neuroimaging</kwd>
        <kwd>diagnostic delay</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Российского научного фонда в рамках научного проекта № 24-18-01061, https://rscf.ru/project/24-18-01061/</funding-statement>
        <funding-statement xml:lang="en">The study was supported by the Russian Science Foundation, project number 24-18-01061, https://rscf.ru/en/project/24-18-01061/</funding-statement>
      </funding-group>
    </article-meta>
  </front>
  <body/>
  <back>
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