Abstract
In today’s rapidly evolving medical landscape, biochips have become one of the most significant tools for diagnosing and treating diseases. These tiny devices allow us to analyze biological samples at the molecular level, opening up new possibilities for early detection and personalized medicine. However, integrating biochips into clinical practice presents a number of challenges, including technological, economic, regulatory, and ethical considerations. The aim of this review is to examine the current state of biochip integration in medical diagnostics, identify key challenges, and propose solutions. We will explore the technological, economic, regulatory, and ethical aspects of biochip use, as well as potential solutions to address these challenges. The potential impact of biochips on the future of medicine was explored in this review. Scientific publications, reports, and reviews on the development and use of biochips in medicine were consulted during the writing process. Special attention was paid to recent research published within the last five years, ensuring the relevance of presented data. The review revealed several key findings: modern biochips like Lab-on-a-Chip and Organ-on-a-Chip demonstrate high efficacy in diagnosing and modeling biological processes. Biochips have been actively used for early detection of cancer and personalized treatment as well as identifying pathogenic microorganisms. The integration of artificial intelligence enhances the diagnostic capabilities of biochips. However, the implementation of this technology is hindered by economic and regulatory challenges such as high costs, strict regulations, ethical concerns, and privacy issues. In addition, the lack of qualified specialists with the necessary knowledge and skills to work with biochips presents additional challenges for their widespread adoption. Biochips represent a revolutionary technology with the potential to significantly enhance the quality of medical diagnostics. However, in order to successfully implement this technology, several key issues must be addressed. These include reducing costs, improving technology, simplifying regulatory procedures, training specialists, and establishing a clear legal framework. Further work should focus on improving technologies, establishing standards, and conducting large-scale clinical trials in order to make biochips more effective and accessible for a wider range of applications.
For citation
Mustafin ShF, Bavarov OA. Introduction of biochips in modern medical diagnostics: Challenges and solutions. USMU Medical Bulletin. 2025;10(2):e00160. (In Russ.). DOI: https://doi.org/10.52420/usmumb.10.2.e00160. EDN: https://elibrary.ru/IHHAUU.
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