Syndrome of Connective Tissue Dysplasia in Children with Nephropathy of Early Age

Abstract

The article presents the results of a study of the manifestations of the syndrome of undifferentiated connective tissue dysplasia (UCTD) in infants and young children with pyelonephritis. Materials and methods. A retrospective analysis of outpatient records of infants and young children with pyelonephritis (n = 69) was carried out, the comparison group included “conditionally healthy” children (n = 35). Symptoms were assessed according to the criteria developed by the experts of the pediatric group “Connective Tissue Dysplasia” at the Russian Scientific Society of Therapists. Results. 88.4 % of children in the main group had signs of UCTD syndrome, in the comparison group these symptoms were detected in 42.9 % (p < 0.001). In the main group, dysplastic signs had the following localization: urinary system (73.9 %), heart (59.4 %), vessels (59.4 %), muscular system (53.6 %). In healthy children, the symptoms of dysplasia were localized mainly in the heart (20.0 %) and the vascular system (14.3 %), which with age can also contribute to the formation of cardiovascular diseases.