Keywords
vitamin D deficiency
risk factors
postmenopause
Abstract
Combined effect of the most significant risk factors for hypovitaminosis D in late postmenopausal women is presented in the article. Inadequate vitamin D supply has become a global issue. Current investigations are focused on the variety of calcidiol supply affecting factors in different populations. Late postmenopausal women are at high risk for D‑deficiency conditions due to hypoestrogenism and age-associated changes in vitamin D metabolism. The aim of the study was to assess the contribution of the most significant vitamin D deficiency risk factors to calcidiol supply in late postmenopausal Ekaterinburg residents. Material and methods. A total of 142 postmenopausal women were enrolled into this cross-sectional study between 2018 and 2021. General clinical data, anthropometric parameters, serum 25(OH)D level assessment (chemiluminescent immunoassay; Access 2, Beckman Coulter, USA) were performed. Results. Statistically significant differences were obtained in calcidiol levels according to a combination of the following groups of factors: body mass index and history of low-dose colecalciferol use, as well as age and waist/hip ratio. Conclusions. Identification of the most significant risk factors for D‑deficient conditions in late postmenopausal women can help timely diagnosis and correction of hypovitaminosis D to realize its skeletal and pleiotropic effects.
For citation
Vikhareva AA, Izmozherova NV, Popov AA, Ryabinina AV. Analysis of risk factors for decreased calcidiol levels in late postmenopausal women: Results of a cross-sectional study. Bulletin of USMU. 2023;(2):52–60. (In Russ.). EDN: https://elibrary.ru/YZUYEB.
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Copyright © 2023 Vikhareva A. A., Izmozherova N. V., Popov A. A., Ryabinina A. V.